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Product Description

Modafinil – selective alpha-1-adrenomimetic mainly central action. There is evidence that modafinil acts through the glutamatergic system and increases the level of synthesis of glutamic acid, inhibiting the release of GABA.

The drug was developed for the treatment of narcolepsy. In 1998, modafinil was the first drug in its class to help wakefulness and resolved in the US. During the trials, patients who took modafinil stayed awake for 28 hours, keeping attention and working capacity.

According to the media, the drug is actively used in the armies of the United States and Britain to correct the performance, primarily for pilots. Modafinil, almost without affecting physical performance, reduces the need for sleep. The only indication for his appointment in clinical medicine was narcolepsy. Can be effectively used to increase concentration.

Effects of Modafinil

When testing a new drug, scientists noted the absence of side effects characteristic of traditional stimulants of the time – amphetamines, ritalin and ephedrine. Due to a special mechanism of action, modafinil does not cause a “recoil effect” like amphetamine, and does not enter into a nervous state like ritalin, while retaining the main effect – increasing the time of wakefulness, relieving stress, fatigue and increasing cognitive abilities.

Modafinil is positioned as a remedy for drowsiness, and in this area practically has no equivalent competitors – users often describe the effect of the drug bodybuilding secrets as “I never sleep, I never eat.” The effects of increasing productivity and cognitive improvement have led to a lot of research, and the Swedish neuroscientist and transhumanist Anders Sandberg, in his speech at the TransVision conference, described modafinil as “perhaps the most approached to date to create an intelligence enhancer drug.”

Of the negative effects can be noted frequent headache, dry mouth and the inherent effects of many nootropic drugs excessive irritability, the so-called “effect of the internal snob”.

Modafinil Properties and mechanism of action

The mechanism of action of modafinil differs from the mechanism of action of amphetamine and ephedrine or other similar psychostimulants. Modafinil also does not form in the human body from derivatives of amphetamine or ephedrine. Adafinil, an older drug than modafinil, is a drug similar to modafinil in structure and effects.

Modafinil affects different parts of the brain. Probably the most important effect is an increase in the speed of mental reactions. This effect refers to the lower part of the intermediate brain, the hypothalamus, where the activation of the neural pathways in which orexin / hypocretin action plays an important role in the regulation of sleep-wakefulness as mediators occurs.

In addition, it activates the sympathetic alpha-1 receptors of the central nervous system, increases the activity of stimulation of glutamine and histamine transmitters, and also enhances the effects of serotonin in the cerebral cortex.

In addition, it reduces the activity of those inhibitory nerve cells in which gamma-aminobutyric acid acts as a transmitter. Modafinil does not lead to excitation of the dopamine system in the central nervous system, which is the most important effect of amphetamines.