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Product Description

Isotretinoin (Accutane) in the body reversibly turns into tretinoin, and about 20-30% of isotretinoin is metabolized by this route. With the repeated administration of the drug, its main metabolite, 4-oxoisotretinoin, accumulates in the blood. Metabolites and the starting material (in the form of conjugates with glucuronic acid) are secreted into bile. T1 / 2 isotretinoin is 6-36 hours. With repeated administration, the steady-state serum concentration is reached after 5-7 days. Some metabolites of isotretinoin disappear from the plasma quite slowly. Because of the possible teratogenic effect of retinoids, women are advised to avoid pregnancy for at least 1 month after stopping their intake. The pharmacokinetics of isotretinoin is reviewed by Allen and Bloxham in Symposium, 1989b.

Pharmachologic effect of Isotretinoin (Accutane)

Retinoid for systemic therapy of acne.

Isotretinoin (Accutane) is a stereoisomer of fully trans-retinoic acid (tretinoin).

The exact mechanism of action of the drug Isotretinoin (Accutane) has not yet been clarified, but it has been established that the improvement of the clinical picture of severe acne forms is associated with suppression of sebaceous gland activity and histologically confirmed decrease in their size. In addition, the anti-inflammatory effect of isotretinoin on the skin has been proven.

Hyperkeratosis of the cells of the epithelium of the hair bulb and the sebaceous gland leads to corneocytes sloughing into the gland duct and to blockage of the latter with keratin and an excess of sebaceous secretion. This is followed by the formation of a comedon and, in some cases, accession

Side effects of Isotretinoin (Accutane)

Isotretinoin (Accutane) is a potent drug with associated side effects. This is a controversial drug. At one time newspapers were rumbling about him, that he can cause fetal defects, depression and cause suicide. Admission during pregnancy bodybuilding secrets can cause serious complications in the development of the fetus. Also, it is somewhat hepatotoxic, can cause inflammation of the intestine, pancreatitis, suppression of good cholesterol and worsen hearing and vision, can also cause psychosis, palpitation, hoarseness, increased intracranial pressure and even deformation of the nasal cartilage if taken after surgery at this site.

Although it is not exactly proven that Isotretinoin (Accutane) can cause depression, psychosis and a propensity for suicide, this possibility can not be taken lightly.

This opportunity was investigated in 2005. 28 people participated in this study, half of them took Isotretinoin (Accutane), and half of them were modern antibiotics. Computed tomography was performed before and after 4 weeks of drug use. They showed changes in the part of the cerebral cortex, in the area that is responsible for depressive conditions. Those taking Isotretinoin (Accutane) in these areas decreased metabolism by 21%, while those taking antibiotics were only 2%.