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Bromocriptine (Parlodel) is classified as a dopamine agonist drug that lowers prolactin levels. Primarily used in Parkinson’s disease patients to lower high prolactin level. Bromocriptine was soon discovered to be of great use in many medical conditions as well as off label uses.

Elevation of dopamine levels may lead to a marked increase in sex drive, improvement in mood, alertness, learning ability and creativity. Known off-label uses for dopaminergic drugs such as Bromocriptine include sex drive enhancement and increased ejaculation volume, mood elevation, appetite suppression and fat loss.

In genetically obese rats, bromocriptine normalizes metabolism and there are many good reasons to think it will do the same in humans. Bromocriptine has use during dieting (to minimize the negative adaptations), muscle gain when very lean, and may be beneficial post-steroid cycle. It may also be useful for diabetes treatment and may have pro-sexual effects.

Bromocriptine is one of those drugs that the life-extention crowd were very big on a few years ago. It is an anti-parkinsons medication which causes higher levels of the neurotransmitter dopamine, with side effects being an increased sex drive, possible curbing of appetite, possible stimulation of CNS, and fat loss. It?s also indicated for some forms of male hypogonadism (yeah, so it may increase test levels on its own!). However, what we?re interested in here is that it can be used to lower prolactin and progesterone.

Bromocriptine has a half-life of roughly 12-14 hours, and dosing is 2.5-5 mg/day taken in the morning.

Another interesting clinical study administered a component of tobacco called DMBA to rats at a level where it is known to be very effective in producing breast cancer. However, rats that had been pretreated with Bromocriptine completely avoided any cancer development. Bromocriptine therefore appears to also offer itself as a very potent free radical quencher.

One of the most recent studies indicates that Bromocriptine may be a candidate for the treatment of Type-2 diabetes. This is because Bromocriptine has been shown to suppress lipogenesis and improve glucose tolerance and insulin resistance.

One animal study suggested that a further action of Bromocriptine is to alter CNS (central nervous system), regulating metabolism and as such, has another important use in helping to prevent weight gain, (this would be in addition to its improvement of diabetic conditions).